Article
A conserved motif at the 3' end of mouse hepatitis virus genomic RNA required for host protein binding and viral RNA replication.
Virology - 1 Dec 1995
Yu W, Leibowitz J L
Abstract excerpt
A conserved 11-nucleotide sequence, UGAAUGAAGUU, at the 3' end of the genomic RNA of coronavirus mouse hepatitis virus was required for host protein binding and viral RNA synthesis. An RNA probe containing this 11-nucleotide sequence bound four cellular proteins with a highly labeled protein of 120 kDa and three minor species with sizes of 103, 81, and 55 kDa. Mutation of the 11-nucleotide motif abolished...
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