Article
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.
The Journal of biological chemistry - 29 Jul 2011
Mostowy Serge, Sancho-Shimizu Vanessa, Hamon Mélanie Anne, Simeone Roxane, Brosch Roland, Johansen Terje, Cossart Pascale
Abstract excerpt
Autophagy is an important mechanism of innate immune defense. We have recently shown that autophagy components are recruited with septins, a new and increasingly characterized cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin. On the other hand, intracytosolic Listeria avoids autophagy recognition by expressing ActA, a bacterial effector required for actin polymerization....
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