Article
The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates
14 Jun 2012
Abstract excerpt
Cell stress and infection promote the formation of ubiquitinated aggregates in both non-immune and immune cells. These structures are recognised by the autophagy receptor p62/sequestosome 1 and are substrates for selective autophagy. The intracellular growth of Salmonella enterica occurs in a membranous compartment, the Salmonella-containing vacuole (SCV), and is dependent on effectors translocated to the host...
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