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Article

Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.

The EMBO journal - 2 May 2007

During Russell L, Gibson Bruce G, Li Wei, Bishai Ellen A, Sidhu Gurjit S, Landry Jacques, Southwick Frederick S

Abstract excerpt

Inhalation of anthrax causes fatal bacteremia, indicating a meager host immune response. We previously showed that anthrax lethal toxin (LT) paralyzes neutrophils, a major component of innate immunity. Here, we have found that LT also inhibits actin-based motility of the intracellular pathogen Listeria monocytogenes. LT inhibition of actin assembly is mediated by blockade of Hsp27 phosphorylation, and can be...

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Identifiers

PMID: 17446863
DOI: 10.1038/sj.emboj.7601687
PMCID: PMC1864983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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