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Article

Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain.

Acta crystallographica. Section D, Biological crystallography - 1 Jun 2011

Meinke Gretchen, Phelan Paul, Fradet-Turcotte Amélie, Archambault Jacques, Bullock Peter A

Abstract excerpt

The modular multifunctional protein large T antigen (T-ag) from simian virus 40 orchestrates many of the events needed for replication of the viral double-stranded DNA genome. This protein assembles into single and double hexamers on specific DNA sequences located at the origin of replication. This complicated process begins when the origin-binding domain of large T antigen (T-ag ODB) binds the GAGGC sequences in...

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PMID: 21636896
DOI: 10.1107/S0907444911014302
PMCID: PMC3107053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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