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Article

Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.

Journal of andrology - 1 Jan 2000

Miyakawa Hiroe, Miyamoto Toshinobu, Koh Eitetsu, Tsujimura Akira, Miyagawa Yasushi, Saijo Yasuaki, Namiki Mikio, Sengoku Kazuo

Abstract excerpt

Genetic mechanisms have been implicated as a cause of some cases of male infertility. Recently, 10 novel genes involved in human spermatogenesis, including human SEPTIN12, were identified by expression microarray analysis of human testicular tissue. Septin12 is a member of the septin family of conserved cytoskeletal GTPases that form heteropolymeric filamentous structures in interphase cells. It is expressed...

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Source

Identifiers

PMID: 21636737
DOI: 10.2164/jandrol.110.012146

Genes

SEPTIN12

Provenance

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Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.PMID 21636737Read ↗

SEPTIN12 genetic variants confer susceptibility to teratozoospermia.Semantic proximity Read ↗

Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men.Semantic proximity Read ↗

Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility.Semantic proximity Read ↗

<i>SEPT12</i>mutations cause male infertility with defective sperm annulusSemantic proximity Read ↗

The expression level of septin12 is critical for spermiogenesis.Semantic proximity Read ↗

The role of the septin family in spermiogenesisSemantic proximity Read ↗

Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysisSemantic proximity Read ↗

SEPTIN12 c.474 G > A polymorphism as a risk factor in teratozoospermic patients.Semantic proximity Read ↗

SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.Semantic proximity Read ↗

A rare frameshift mutation inSYCP1is associated with human male infertilitySemantic proximity Read ↗

Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization FailureSemantic proximity Read ↗

Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.Semantic proximity Read ↗

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