Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

doi:10.1007/s00280-021-04327-w

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Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

Cancer chemotherapy and pharmacology - 1 Nov 2021

Fernandes Marianne Rodrigues, Rodrigues Juliana Carla Gomes, Dobbin Elizabeth Ayres Fragoso, Pastana Lucas Favacho, da Costa Danielle Feio, Barra Williams Fernandes, Modesto Antônio André Conde, de Assumpção Paula Baraúna, da Costa Silva Artur Luiz, Dos Santos Sidney Emanuel Batista, Burbano Rommel Mario Rodriguez, de Assumpção Paulo Pimentel, Dos Santos Ney Pereira Carneiro

Abstract excerpt

PURPOSE: Fluoropyrimidines are one of the most used drug class to treat cancer patients, although they show high levels of associated toxicity. This study analyzed 33 polymorphisms in 17 pharmacogenes involved with the pharmacogenomics of fluoropyrimidines, in gastrointestinal cancer patients undergoing fluoropyrimidine-based treatment in the Brazilian Amazon. METHODS: The study population was composed of 216...

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PMID: 34331561
DOI: 10.1007/s00280-021-04327-w

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