Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiation-generated short DNA fragments may perturb non-homologous end-joining and induce genomic instability.

Journal of radiation research - 1 Jan 2011

Pang Dalong, Winters Thomas A, Jung Mira, Purkayastha Shubhadeep, Cavalli Luciane R, Chasovkikh Sergey, Haddad Bassem R, Dritschilo Anatoly

Abstract excerpt

Cells exposed to densely ionizing radiation (high-LET) experience more severe biological damage than do cells exposed to sparsely ionizing radiation (low-LET). The prevailing hypothesis is that high-LET radiations induce DNA double strand-breaks (DSB) that are more complex and clustered, and are thereby more challenging to repair. Here, we present experimental data obtained by atomic force microscopy imaging,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA Fragmentation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

Share to Genomic Instability

Share to Mutation

Share to Radiation Dosage

Source

Open in PubMed Open full text

Identifiers

PMID: 21628845
DOI: 10.1269/jrr.10147
PMCID: PMC5469405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiation-generated short DNA fragments may perturb non-homologous end-joining and induce genomic instability.PMID 21628845Read ↗

Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualizationSemantic proximity Read ↗

DNA Double Strand Break Repair: A Radiation PerspectiveSemantic proximity Read ↗

DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin BreaksSemantic proximity Read ↗

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?Semantic proximity Read ↗

The Clustered DNA Lesions – Types, Pathways of Repair and Relevance to Human HealthSemantic proximity Read ↗

Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological SignificanceSemantic proximity Read ↗

DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation.Semantic proximity Read ↗

3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiationSemantic proximity Read ↗

DNA double-strand breaks in and beyond heavy-ion tracks: the role of Base Excision Repair and DNA-damage complexitySemantic proximity Read ↗

Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells.Semantic proximity Read ↗

Sensing and repairing DNA double-strand breaks.Semantic proximity Read ↗

Cellular responses to DNA double-strand breaks after low-dose γ-irradiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.