Article
Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.
Genome biology - 1 Jan 2011
Gokcumen Omer, Babb Paul L, Iskow Rebecca C, Zhu Qihui, Shi Xinghua, Mills Ryan E, Ionita-Laza Iuliana, Vallender Eric J, Clark Andrew G, Johnson Welkin E, Lee Charles
Abstract excerpt
BACKGROUND: Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation. RESULTS: In this study, we identified over 2,000 human CNVs that overlap with orthologous chimpanzee or orthologous macaque CNVs. Of these, 170 CNVs overlap with both chimpanzee and macaque CNVs, and these were collapsed into 34 hotspot regions of CNV formation. Many of these...
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