Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced purifying selection prevails over positive selection in human copy number variant evolution.

Genome research - 1 Nov 2008

Nguyen Duc-Quang, Webber Caleb, Hehir-Kwa Jayne, Pfundt Rolph, Veltman Joris, Ponting Chris P

Abstract excerpt

Copy number variation is a dominant contributor to genomic variation and may frequently underlie an individual's variable susceptibilities to disease. Here we question our previous proposition that copy number variants (CNVs) are often retained in the human population because of their adaptive benefit. We show that genic biases of CNVs are best explained, not by positive selection, but by reduced efficiency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Chromosomes, Artificial, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to GC Rich Sequence

Share to Gene Dosage

Share to Genome, Human

Share to Selection, Genetic

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18687881
DOI: 10.1101/gr.077289.108
PMCID: PMC2577867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced purifying selection prevails over positive selection in human copy number variant evolution.PMID 18687881Read ↗

Bias of selection on human copy-number variants.Semantic proximity Read ↗

Mutational and selective effects on copy-number variants in the human genome.Semantic proximity Read ↗

Exploring the role of copy number variants in human adaptation.Semantic proximity Read ↗

Global diversity, population stratification, and selection of human copy-number variation.Semantic proximity Read ↗

Dosage sensitivity is a major determinant of human copy number variant pathogenicity.Semantic proximity Read ↗

Copy number variation in human health, disease, and evolution.Semantic proximity Read ↗

Copy number variation and evolution in humans and chimpanzees.Semantic proximity Read ↗

Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.Semantic proximity Read ↗

Dosage sensitivity shapes the evolution of copy-number varied regions.Semantic proximity Read ↗

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease.Semantic proximity Read ↗

Population analysis of large copy number variants and hotspots of human genetic disease.Semantic proximity Read ↗

The functional impact of copy number variation in the human genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.