Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the role of copy number variants in human adaptation.

Trends in genetics : TIG - 1 Jun 2012

Iskow Rebecca C, Gokcumen Omer, Lee Charles

Abstract excerpt

Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of genomic material) in the genomes of healthy humans has become apparent. Although some of these variants are associated with disorders, a handful of studies documented an adaptive advantage conferred by CNVs. In this review, we propose that CNVs are substrates for human evolution and adaptation. We discuss the possible mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to DNA Copy Number Variations
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22483647
DOI: 10.1016/j.tig.2012.03.002
PMCID: PMC3533238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the role of copy number variants in human adaptation.PMID 22483647Read ↗

Mutational and selective effects on copy-number variants in the human genome.Semantic proximity Read ↗

Copy number variation in human health, disease, and evolution.Semantic proximity Read ↗

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease.Semantic proximity Read ↗

The clinical context of copy number variation in the human genome.Semantic proximity Read ↗

Copy number variations in the human genome and strategies for analysis.Semantic proximity Read ↗

Copy number variation: new insights in genome diversity.Semantic proximity Read ↗

Human copy number variation and complex genetic disease.Semantic proximity Read ↗

CNVs and genetic medicine (excitement and consequences of a rediscovery).Semantic proximity Read ↗

Copy-Number Variations, Noncoding Sequences, and Human PhenotypesSemantic proximity Read ↗

DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspectsSemantic proximity Read ↗

Gene copy number variation and common human disease.Semantic proximity Read ↗

Implications of gene copy-number variation in health and diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.