Article
Copy number variation: new insights in genome diversity.
Genome research - 1 Aug 2006
Freeman Jennifer L, Perry George H, Feuk Lars, Redon Richard, McCarroll Steven A, Altshuler David M, Aburatani Hiroyuki, Jones Keith W, Tyler-Smith Chris, Hurles Matthew E, Carter Nigel P, Scherer Stephen W, Lee Charles
Abstract excerpt
DNA copy number variation has long been associated with specific chromosomal rearrangements and genomic disorders, but its ubiquity in mammalian genomes was not fully realized until recently. Although our understanding of the extent of this variation is still developing, it seems likely that, at least in humans, copy number variants (CNVs) account for a substantial amount of genetic variation. Since many CNVs...
Topics
- Animals
- Biological Evolution
- Chromosome Mapping
- Gene Dosage
- Gene Expression
- Genome, Human
- Humans
- Phenotype