Article
Hotspots for copy number variation in chimpanzees and humans.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006
Perry George H, Tchinda Joelle, McGrath Sean D, Zhang Junjun, Picker Simon R, Cáceres Angela M, Iafrate A John, Tyler-Smith Chris, Scherer Stephen W, Eichler Evan E, Stone Anne C, Lee Charles
Abstract excerpt
Copy number variation is surprisingly common among humans and can be involved in phenotypic diversity and variable susceptibility to complex diseases, but little is known of the extent of copy number variation in nonhuman primates. We have used two array-based comparative genomic hybridization platforms to identify a total of 355 copy number variants (CNVs) in the genomes of 20 wild-born chimpanzees (Pan...
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