Article
Copy number variation and evolution in humans and chimpanzees.
Genome research - 1 Nov 2008
Perry George H, Yang Fengtang, Marques-Bonet Tomas, Murphy Carly, Fitzgerald Tomas, Lee Arthur S, Hyland Courtney, Stone Anne C, Hurles Matthew E, Tyler-Smith Chris, Eichler Evan E, Carter Nigel P, Lee Charles, Redon Richard
Abstract excerpt
Copy number variants (CNVs) underlie many aspects of human phenotypic diversity and provide the raw material for gene duplication and gene family expansion. However, our understanding of their evolutionary significance remains limited. We performed comparative genomic hybridization on a single human microarray platform to identify CNVs among the genomes of 30 humans and 30 chimpanzees as well as fixed copy number...
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