Article
A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection.
Behavior genetics - 1 Sept 2011
Kwan Johnny S H, Kung Annie W C, Sham Pak C
Abstract excerpt
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
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