Article
Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: virological breakthrough is also dependent on adherence to medication.
Scandinavian journal of gastroenterology - 1 Sept 2011
Kamezaki Hidehiro, Kanda Tatsuo, Wu Shuang, Nakamoto Shingo, Arai Makoto, Maruyama Hitoshi, Fujiwara Keiichi, Imazeki Fumio, Yokosuka Osamu
Abstract excerpt
OBJECTIVE: Currently, five nucleos(t)ide analogues (NUCs) are available for the treatment of chronic hepatitis B in the world. We examined the prevalence of hepatitis B virus (HBV) DNA and alanine aminotransferase normalization in patients receiving entecavir (ETV) and the frequency of ETV-resistant mutations during an approximately 27-month use of ETV in chronic hepatitis B patients in an urban hospital in...
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