Article
Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.
Journal of lipid research - 1 Sept 2011
Leduc Magalie S, Hageman Rachael S, Verdugo Ricardo A, Tsaih Shirng-Wern, Walsh Kenneth, Churchill Gary A, Paigen Beverly
Abstract excerpt
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet. We identified one significant QTL on chromosome (Chr) 15 and three suggestive QTL on Chrs 2, 7, and 17. We also carried out microarray analysis on the livers of parental strains of 282 F2...
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