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Mutations in the dimer interfaces of the dengue virus capsid protein affect structural stability and impair RNA-capsid interaction

26 Feb 2019

Abstract excerpt

The dengue virus 2 capsid protein (DENV2C) plays a primary structural role in the protection of the viral genome and is crucial for nucleocapsid assembly. In this study, we generated single mutants of DENV2C at L50 and L54 residues of the α2 helix, which was shown to interfere with the integration of the capsid into lipid droplets, and at residues L81 and I88 located in the α4 helix, which was shown to affect...

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PMID: 30808916
DOI: 10.1038/s41598-019-39185-3

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