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Article

Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding.

PloS one - 1 Jan 2012

Tarus Bogdan, Chevalier Christophe, Richard Charles-Adrien, Delmas Bernard, Di Primo Carmelo, Slama-Schwok Anny

Abstract excerpt

The influenza viruses contain a segmented, negative stranded RNA genome. Each RNA segment is covered by multiple copies of the nucleoprotein (NP). X-ray structures have shown that NP contains well-structured domains juxtaposed with regions of missing electron densities corresponding to loops. In this study, we tested if these flexible loops gated or promoted RNA binding and RNA-induced oligomerization of NP. We...

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Source

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Identifiers

PMID: 22272272
DOI: 10.1371/journal.pone.0030038
PMCID: PMC3260217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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