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Article

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease

10 Feb 2017

Abstract excerpt

The objective of our study was to better understand the protective effects of the mitochondria-targeted tetra-peptide SS31 against amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD) progression. Using intraperitoneal injections, we administered SS31 to an AD mouse model (APP) over a period of 6 weeks, beginning when the APP mice were 12 months of age. We studied their...

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PMID: 28186562
DOI: 10.1093/hmg/ddx052

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