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Article

Internal deletions in the yeast transcriptional activator HAP1 have opposite effects at two sequence elements.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990

Kim K S, Pfeifer K, Powell L, Guarente L

Abstract excerpt

In this report we study the effects of internal deletions of the yeast transcriptional activator HAP1 (CYP1) on activity at two dissimilar DNA binding sites, upstream activation sequence 1 (UAS1) of CYC1 (iso-1-cytochrome c) and CYC7 (iso-2-cytochrome c). These deletions remove up to 1061 amino acids of the 1483-residue protein and bring the carboxyl-terminal acidic activation domain closer to the amino-terminal...

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Source

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Identifiers

PMID: 2162046
DOI: 10.1073/pnas.87.12.4524
PMCID: PMC54148

Genes

HAP1
CYC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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