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Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor

25 May 2012

Abstract excerpt

BACKGROUND: A disintegrin and metalloproteinase 28 (ADAM28) is implicated in tumor growth and metastasis in human breast and non-small cell lung carcinomas. We explored the mechanism of ADAM28-mediated metastasis by searching for new substrates of ADAM28. METHODS: We used a yeast two-hybrid system to screen the human lung cDNA library for ADAM28-binding proteins and identified von Willebrand factor (VWF) as a...

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PMID: 22636800
DOI: 10.1093/jnci/djs232

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