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Article

Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2011

Yamaoka Toshimitsu, Frey Mark R, Dise Rebecca S, Bernard Jessica K, Polk D Brent

Abstract excerpt

Upon ligand binding, epidermal growth factor (EGF) receptor (R) autophosphorylates on COOH-terminal tyrosines, generating docking sites for signaling partners that stimulate proliferation, restitution, and chemotaxis. Specificity for individual EGFR tyrosines in cellular responses has been hypothesized but not well documented. Here we tested the requirement for particular tyrosines, and associated downstream...

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Source

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Identifiers

PMID: 21617115
DOI: 10.1152/ajpgi.00327.2010
PMCID: PMC3154598

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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