Article
Potentiation of a polyadenylylation site by a downstream protein-DNA interaction.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Dorsett D
Abstract excerpt
The gypsy retroposon of Drosophila melanogaster contains a sequence that potentiates upstream polyadenylylation sites. In contrast to other sequences that influence poly(A) site use, it appears to operate at the level of the DNA template. Nuclear extracts contained protein that bound to a repeated motif in the DNA. Flies with mutations that reduced transcripts polyadenylylated in the 5' long terminal repeat of...
Topics
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA Transposable Elements
- DNA-Binding Proteins
- Drosophila melanogaster
- Gene Expression
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Poly A