Article
Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers.
Clinical chemistry - 1 Sept 2004
Steimer Werner, Zöpf Konstanze, von Amelunxen Silvia, Pfeiffer Herbert, Bachofer Julia, Popp Johannes, Messner Barbara, Kissling Werner, Leucht Stefan
Abstract excerpt
BACKGROUND: Recently, new polymorphisms were described in connection with intermediate and ultrarapid CYP2D6 metabolism. These may allow a much desired prediction of metabolic activity within the extensive metabolizer group. The functional consequences are still being discussed with few data available for clinical patients. METHODS: We conducted a prospective, blinded two-center study seeking correlations between...
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