ABCB1 (P-Glycoprotein/MDR1) Gene G2677T/A Sequence Variation (Polymorphism): Lack of Association with Side Effects and Therapeutic Response in Depressed Inpatients Treated with Amitriptyline

Abstract excerpt

Amitriptyline belongs to the class of tricyclic antidepressants (TCAs), which have been a cornerstone of antidepressive therapy for more than 4 decades. Despite being replaced by newer drugs in the United States, TCAs, and amitriptyline in particular, are still widely used in Europe and many parts of the world, where prescriptions for TCAs far outnumber those for newer, more expensive drugs. Recently, we reported...

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