Article
Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2014
Wu Lang, Goldstein Alisa M, Yu Kai, Yang Xiaohong Rose, Rabe Kari G, Arslan Alan A, Canzian Federico, Wolpin Brian M, Stolzenberg-Solomon Rachael, Amundadottir Laufey T, Petersen Gloria M
Abstract excerpt
BACKGROUND: Melanoma cases may exist in pancreatic cancer kindreds, whereas there is increased risk of pancreatic cancer in familial melanoma. The two cancers may share genetic susceptibility variants in common. METHODS: Three dbGaP (datasets in Genotypes and Phenotypes)-deposited GWAS (genome-wide association study) datasets (MD Anderson melanoma, PanScan 1, and PanScan 2 for pancreatic cancer) were used....
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