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Article

Heterozygosity loss at 22q and lack of INI1 gene mutation in gastrointestinal stromal tumor.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2011

Yamamoto Hidetaka, Kohashi Kenichi, Tsuneyoshi Masazumi, Oda Yoshinao

Abstract excerpt

OBJECTIVES: Gastrointestinal stromal tumor (GIST) is characterized by KIT or PDGFRA gene mutation. Although chromosomal losses of 22q are frequent in GIST, it is unclear which tumor suppressor genes might be inactivated in association with such losses. The INI1 gene, located at 22q11.23, is a tumor suppressor gene that is frequently altered in malignant rhabdoid tumor. METHODS: To elucidate the hypothesis that...

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Share to Chromosomal Proteins, Non-Histone
Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Gastrointestinal Stromal Tumors

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to SMARCB1 Protein

Source

Identifiers

PMID: 21613800
DOI: 10.1159/000323564

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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