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Article

Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q.

Journal of cancer research and clinical oncology - 1 Jun 2009

Yamamoto Hidetaka, Tobo Taro, Nakamori Mari, Imamura Masakazu, Kojima Aya, Oda Yoshinao, Nakamura Norimoto, Takahira Tomonari, Yao Takashi, Tsuneyoshi Masazumi

Abstract excerpt

PURPOSE: Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular pathogenetic mechanisms of NF-1-related GISTs (NF-1 GISTs) remain unclear. METHODS: Thirty-one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19020900
DOI: 10.1007/s00432-008-0514-z

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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