Article
The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.
The EMBO journal - 15 Sept 1999
Patel D, Huang S M, Baglia L A, McCance D J
Abstract excerpt
The co-activators CBP and p300 are important for normal cell differentiation and cell cycle progression and are the targets for viral proteins that dysregulate these cellular processes. We show here that the E6 protein from the oncogenic human papillomavirus type 16 (HPV-16) binds to three regions (C/H1, C/H3 and the C-terminus) of both CBP and p300. The interaction of E6 with CBP/p300 was direct and independent...
Topics
- Animals
- Binding Sites
- Cell Cycle
- Cell Differentiation
- Cell Line
- Genes, p53
- Humans
- Mutation
- NF-kappa B
- Nuclear Proteins
- Oncogene Proteins, Viral
- Papillomaviridae
- Peptide Mapping
- Protein Binding
- Recombinant Fusion Proteins
- Repressor Proteins
- Trans-Activators
- Transcriptional Activation