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Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6

5 Apr 2015

Abstract excerpt

Recent cancer genomics studies have identified mutation patterns characteristic of APOBEC3B (A3B) in multiple cancers, including cervical cancer, which is caused by human papillomavirus (HPV) infection. A3B expression is upregulated by HPV E6/E7 oncoproteins, implying a crucial role for A3B upregulation in HPV-induced carcinogenesis. Here, we explored the molecular mechanisms underlying the activation of the A3B...

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PMID: 25800874
DOI: 10.1016/j.bbrc.2015.03.068

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