Article
Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.
Neurobiology of aging - 1 Mar 2012
Ohgami Nobutaka, Ida-Eto Michiru, Sakashita Naomi, Sone Michihiko, Nakashima Tsutomu, Tabuchi Keiji, Hoshino Tomofumi, Shimada Atsuyoshi, Tsuzuki Toyonori, Yamamoto Masahiko, Sobue Gen, Jijiwa Mayumi, Asai Naoya, Hara Akira, Takahashi Masahide, Kato Masashi
Abstract excerpt
c-Ret has been shown to be crucial for neural development and survival. We have recently shown that complete impairment of tyrosine 1062 (Y1062)-phosphorylation in c-Ret causes congenital hearing loss with neurodegeneration of spiral ganglion neurons (SGNs) in homozygous c-Ret knockin mice (c-Ret-KI(Y1062F/Y1062F)-mice). However, there is no information to link c-Ret and age-related hearing loss. Here we show...
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