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Article

Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models.

Hearing research - 1 Nov 2024

Yang Ting-Hua, Hsu Yu-Chen, Yeh Peng, Hung Chia-Jui, Tsai Yu-Fei, Fang Mo-Chu, Yen Alice Chih Chia, Chen Li-Fu, Pan Jhih-Yu, Wu Chen-Chi, Liu Tien-Chen, Chung Fong-Ling, Yu Wei-Ming, Lin Shu-Wha

Abstract excerpt

Mutations in various type II transmembrane serine protease (TMPRSS) family members are associated with non-syndromic hearing loss, with some mechanisms still unclear. For instance, the mechanism underlying profound hearing loss and tectorial membrane (TM) malformations in hepsin/TMPRSS1 knockout (KO) mice remains elusive. In this study, we confirmed significantly elevated hearing thresholds and abnormal TM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39437584
DOI: 10.1016/j.heares.2024.109134
PMCID: PMC11531994

Genes

TECTA
TECTB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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