Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis.

Abstract excerpt

Autophagy is often found in apoptosis-defective cancer cells and contributes to chemotherapy resistance. However, it is far from clear how the coordination of apoptosis and autophagy determines sensitivity of cancer cells to chemotherapy. Our recent study showed that Beclin 1, a key regulator of autophagy, is cleaved by caspase 8 at the execution stage of chemotherapy-induced and mitochondria-mediated apoptosis....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis Regulatory Proteins
• Share to Autophagy
• Share to Beclin-1