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Article

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

Cancer research - 15 May 2011

Li Hua, Wang Peng, Sun Quanhong, Ding Wen-Xing, Yin Xiao-Ming, Sobol Robert W, Stolz Donna B, Yu Jian, Zhang Lin

Abstract excerpt

Autophagy is an evolutionarily conserved stress response mechanism that often occurs in apoptosis-defective cancer cells and can protect against cell death. In this study, we investigated how apoptosis and autophagy affect each other in cancer cells in response to chemotherapeutic treatment. We f...

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Identifiers

PMID: 21444671
DOI: 10.1158/0008-5472.CAN-10-4475
PMCID: PMC3096685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21444671-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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