Article
Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes.
The FEBS journal - 1 Feb 2015
Søndergaard Mads T, Sorensen Anders B, Skov Louise L, Kjaer-Sorensen Kasper, Bauer Mikael C, Nyegaard Mette, Linse Sara, Oxvig Claus, Overgaard Michael T
Abstract excerpt
Calmodulin (CaM) is the central mediator of intracellular Ca(2+) signalling in cardiomyocytes, where it conveys the intricate Ca(2+) transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion can lead to...
Topics
- Animals
- Calcium Signaling
- Calmodulin
- Mutation
- Protein Folding
- Tachycardia, Ventricular
- Zebrafish
- Zebrafish Proteins