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Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse.

Archives of gynecology and obstetrics - 1 Jun 2012

Ferrari Maria Maddalena, Rossi Gabriela, Biondi Maria Luisa, Viganò Paola, Dell'utri Chiara, Meschia Michele

Abstract excerpt

AIM: To evaluate whether the presence of specific polymorphism in the gene promoter of collagen and some matrix metalloproteinases was associated with the risk of developing pelvic organ prolapse. METHODS: A case-control study was carried on 233 women: 137 were cases with ≥ stage II pelvic organ prolapse and 96 were matched controls without pelvic pathologies. Allele and genotype frequencies related to...

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PMID: 22210296
DOI: 10.1007/s00404-011-2199-9

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