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Article

Rapamycin Ameliorates Dystrophic Phenotype in mdx Mouse Skeletal Muscle

20 May 2011

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked, lethal, degenerative disease that results from mutations in the dystrophin gene, causing necrosis and inflammation in skeletal muscle tissue. Treatments that reduce muscle fiber destruction and immune cell infiltration can ameliorate DMD pathology. We treated the mdx mouse, a model for DMD, with the immunosuppressant drug rapamycin (RAPA) both locally and...

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PMID: 21607286
DOI: 10.2119/molmed.2010.00256

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