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Article

Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy

2 May 2013

Abstract excerpt

Pathological phenotypes in inclusion body myopathy (IBM) associated with Paget disease of the bone (PDB), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (IBMPFD/ALS) include defective autophagosome and endosome maturation that result in vacuolation, weakness and muscle atrophy. The link between autophagy and IBMPFD/ALS pathobiology has been poorly understood. We examined the AKT-FOXO3 and...

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PMID: 23439279
DOI: 10.4161/auto.23958

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