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The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages

30 Mar 2022

Abstract excerpt

Immaturity of alveolar macrophages (AMs) around birth contributes to the susceptibility of newborns to lung disease. However, the molecular features differentiating neonatal and mature, adult AMs are poorly understood. In this study, we identify the unique transcriptomes and enhancer landscapes of neonatal and adult AMs in mice. Although the core AM signature was similar, murine adult AMs expressed higher levels...

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PMID: 35354612
DOI: 10.4049/jimmunol.2101192

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