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Article

Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins.

Nucleic acids research - 25 Jun 1992

Weston K

Abstract excerpt

The chicken c-myb gene and the v-myb oncogene transduced by avian myeloblastosis virus (AMV) encode DNA binding transcription activators. The DNA binding domain of AMV v-Myb displays a number of amino acid changes relative to c-Myb; v-Myb proteins in which one or more of three crucial residues in the DNA binding domain are mutated to resemble the c-Myb sequence display altered transformation phenotypes. In order...

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Identifiers

PMID: 1620600
DOI: 10.1093/nar/20.12.3043
PMCID: PMC312435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins.PMID 1620600Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

Characterization of the v-myb DNA binding domain.Semantic proximity Read ↗

Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.Semantic proximity Read ↗

Binding site analysis of c-Myb: screening of potential binding sites by using the mutation matrix derived from systematic binding affinity measurements.Semantic proximity Read ↗

Myb-induced transformation.Semantic proximity Read ↗

Analysis of the v-myb structural components important for transactivation of gene expression.Semantic proximity Read ↗

The chicken A-myb protein is a transcriptional activator.Semantic proximity Read ↗

Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.Semantic proximity Read ↗

Transformation by v-myb correlates with trans-activation of gene expression.Semantic proximity Read ↗

Trans-activation by the Drosophila myb gene product requires a Drosophila homologue of CBP.Semantic proximity Read ↗

Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.Semantic proximity Read ↗

Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Semantic proximity Read ↗

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