Article
A canine model of Cohen syndrome: Trapped Neutrophil Syndrome.
BMC genomics - 23 May 2011
Shearman Jeremy R, Wilton Alan N
Abstract excerpt
BACKGROUND: Trapped Neutrophil Syndrome (TNS) is a common autosomal recessive neutropenia in Border collie dogs. RESULTS: We used a candidate gene approach and linkage analysis to show that the causative gene for TNS is VPS13B. We chose VPS13B as a candidate because of similarities in clinical signs between TNS and Cohen syndrome, in human, such as neutropenia and a typical facial dysmorphism. Linkage analysis...
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