Article
An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed.
G3 (Bethesda, Md.) - 8 Sept 2016
Forman Oliver P, Hitti Rebekkah J, Pettitt Louise, Jenkins Christopher A, O'Brien Dennis P, Shelton G Diane, De Risio Luisa, Quintana Rodrigo Gutierrez, Beltran Elsa, Mellersh Cathryn
Abstract excerpt
Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age. Using a genome-wide association study approach with three cases and 170 breed matched controls, a suggestive locus for sensory neuropathy was identified that was followed up using a genome sequencing...
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