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Article

Thrombin generation in haemophilia A patients with mutations causing factor VIII assay discrepancy.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jul 2010

Gilmore R, Harmon S, Gannon C, Byrne M, O'Donnell J S, Jenkins P V

Abstract excerpt

Up to 40% of patients with mild haemophilia A have a discrepancy whereby factor VIII (FVIII) measurements by a two-stage chromogenic assay (FVIII:C(CH)) are disproportionately reduced compared with the FVIII one-stage clotting value (FVIII:C). Which assay best reflects the coagulation potential and clinical phenotype in this patient group is of clinical significance, yet remains unclear. We have assessed the...

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PMID: 20148980
DOI: 10.1111/j.1365-2516.2009.02190.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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