Article
The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.
Genes & development - 1 Mar 1990
Kim S K, Horvitz H R
Abstract excerpt
As a first step in a molecular dissection of the pathway controlling the determination of vulval cell fates in Caenorhabditis elegans, we have analyzed the gene lin-10. We show that loss-of-function mutations in this gene specifically prevent the induction of vulval cell lineages and result instead in the expression of hypodermal cell lineages. We isolated a transposon-insertion allele of lin-10 and used it to...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Cloning, Molecular
- DNA Transposable Elements
- Female
- Gene Expression