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Article

Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.

Development (Cambridge, England) - 1 Dec 1998

Nilsson L, Li X, Tiensuu T, Auty R, Greenwald I, Tuck S

Abstract excerpt

Induction of vulval fates in the C. elegans hermaphrodite is mediated by a signal transduction pathway involving Ras and MAP kinase. Previous genetic analysis has suggested that two potential targets of this pathway in the vulva precursor cells are two novel proteins, LIN-25 and SUR-2. In this report, we describe further studies of lin-25. The results of a genetic mosaic analysis together with those of...

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PMID: 9806929
DOI: 10.1242/dev.125.23.4809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.PMID 9806929Read ↗

lin-25, a gene required for vulval induction in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains.Semantic proximity Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.Semantic proximity Read ↗

Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.Semantic proximity Read ↗

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.Semantic proximity Read ↗

Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

Role of a raf proto-oncogene during Caenorhabditis elegans vulval development.Semantic proximity Read ↗

PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis.Semantic proximity Read ↗

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