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Article

Inhibition of RNA interference and modulation of transposable element expression by cell death in Drosophila.

Genetics - 1 Aug 2011

Xie Weiwu, Liang Chengzhi, Birchler James A

Abstract excerpt

RNA interference (RNAi) regulates gene expression by sequence-specific destruction of RNA. It acts as a defense mechanism against viruses and represses the expression of transposable elements (TEs) and some endogenous genes. We report that mutations and transgene constructs that condition cell death suppress RNA interference in adjacent cells in Drosophila melanogaster. The reversal of RNAi is effective for both...

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Identifiers

PMID: 21596898
DOI: 10.1534/genetics.111.128470
PMCID: PMC3176087

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