Mutational analysis of simian virus 40 small-t antigen.

doi:10.1128/JVI.64.6.2895-2900.1990

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Article

Mutational analysis of simian virus 40 small-t antigen.

Journal of virology - 1 Jun 1990

Jog P, Joshi B, Dhamankar V, Imperiale M J, Rutila J, Rundell K

Abstract excerpt

Several point mutations in the simian virus 40 (SV40) small-t antigen have been analyzed for their effects on protein stability, transformation, transactivation, and binding of two cellular proteins. All mutations which affected cysteine residues in two cysteine clusters produced highly unstable...

Topics

Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Cell Line
Cell Transformation, Viral
Chromosome Deletion
DNA Replication
Molecular Sequence Data
Mutation
Plasmids
Simian virus 40
Theophylline
Transcriptional Activation

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