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Article

Sequencing of Sylvilagus VDJ genes reveals a new VHa allelic lineage and shows that ancient VH lineages were retained differently in leporids.

Immunogenetics - 1 Dec 2014

Pinheiro Ana, Melo-Ferreira José, Abrantes Joana, Martinelli Nicola, Lavazza Antonio, Alves Paulo C, Gortázar Christian, Esteves Pedro J

Abstract excerpt

Antigen recognition by immunoglobulins depends upon initial rearrangements of heavy chain V, D, and J genes. In leporids, a unique system exists for the VH genes usage that exhibit highly divergent lineages: the VHa allotypes, the Lepus sL lineage and the VHn genes. For the European rabbit (Oryctolagus cuniculus), four VHa lineages have been described, the a1, a2, a3 and a4. For hares (Lepus sp.), one VHa lineage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25267061
DOI: 10.1007/s00251-014-0807-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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