Article
Genetic polymorphism at the C-terminal domain (region III) of knob-associated histidine-rich protein (KAHRP) of Plasmodium falciparum in isolates from Iran.
Parasitology research - 1 Dec 2011
Mardani Ahmad, Keshavarz Hossein, Heidari Aliehsan, Hajjaran Homa, Raeisi Ahmad, Khorramizadeh Mohammad Reza
Abstract excerpt
The knob-associated histidine-rich protein (KAHRP) plays a major role in the virulence of Plasmodium falciparum and is one of the targets for molecular therapy. The primary structure of KAHRP of P. falciparum consists of three domains (regions I-III), of which the C-terminal domain (region III) is the most polymorphic segment of this protein. One of the main obstacles is genetic diversity in designing and...
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